Dissertation Defense: Biomedical Photoacoustic Sensing and Imaging: from Cellular Level to Tissue Level

Date: 2023/05/23 - 2023/05/23

Dissertation Title: Biomedical Photoacoustic Sensing and Imaging: from Cellular Level to Tissue Level

Speaker: Nan Wan, Ph.D. candidate at UM-SJTU Joint Institute

Time: May 23rd from 1:00 p.m., 2023 (Beijing Time)

Location: Room 403, Longbin Building


Photoacoustics in biomedicine was researched and developed for more than twenty years. The unique features of photoacoustics in biomedicine involve two parts: optical absorption providing high sensitivity of biosensing or high imaging contrast for bioimaging, and ultrasound detection providing high penetration depth of biological tissue. Based on these two advantages, various biomedical applications were studied and achieved, and mainly concentrated on the diseases related to vessels morphology, blood oxygen saturation and melanoma. However, the understanding of how photoacoustics can interact with other important components in human body is still lacking, and it limits exploiting photoacoustics for biomedical sensing and imaging. Therefore, the author investigated photoacoustics at cellular, molecular and tissue level. Specifically, the author studied photoacoustics from cancer cells, triglyceride molecules and implantable devices encapsulated by tissue, and showed the feasibility of using photoacoustics for identifying cancer cell cycle, diagnosing hypertriglyceridemia and individual identification, correspondingly.


Nan Wan received his B.S. degree and M.S. degree in the major of Precision Instrument from Chongqing University in 2016 and 2019, respectively. Also, he joined the Micro Analysis Systems Laboratory in the University of Tennessee, Knoxville for biochemical molecules detection research in 2018. He then joined the University of Michigan-Shanghai Jiao Tong University Joint Institute in 2019 as a graduate student. His research interest is developing photoacoustic imaging systems for multiple applications.